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J Infect Dis. 2014 Jul 15;209 Suppl 3:S100-6. doi: 10.1093/infdis/jiu147.

Biological differences between the sexes and susceptibility to tuberculosis.

Author information

  • 1KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.

Abstract

Globally, far more men than women have tuberculosis. Although the cause of this bias is uncertain, epidemiological factors have historically been considered the driving force. Here, we discuss evidence that biological differences between the sexes may also be important and can affect susceptibility to mycobacterial infection. We discuss the possible underlying mechanisms, with particular focus on how sex hormones modulate the immune responses necessary for resistance to tuberculosis. Studying these differences may provide valuable insight into the components that constitute an effective immune response to this deadly pathogen.

KEYWORDS:

gender; immunity; male-bias; sex hormones; tuberculosis

PMID:
24966189
DOI:
10.1093/infdis/jiu147
[PubMed - indexed for MEDLINE]
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