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Thromb Haemost. 2014 Oct;112(4):666-77. doi: 10.1160/TH14-02-0126. Epub 2014 Jun 26.

The role of platelets in sepsis.

Author information

1
Sacha F. de Stoppelaar, MD, Academic Medical Centre, Centre of Experimental and Molecular Medicine, Meibergdreef 9, Room G2-130, 1105 AZ Amsterdam, the Netherlands, Tel.: +31 20 5665910, Fax: +31 20 6977192, E-mail: s.f.destoppelaar@amc.uva.nl.

Abstract

Platelets are small circulating anucleate cells that are of crucial importance in haemostasis. Over the last decade, it has become increasingly clear that platelets play an important role in inflammation and can influence both innate and adaptive immunity. Sepsis is a potentially lethal condition caused by detrimental host response to an invading pathogen. Dysbalanced immune response and activation of the coagulation system during sepsis are fundamental events leading to sepsis complications and organ failure. Platelets, being major effector cells in both haemostasis and inflammation, are involved in sepsis pathogenesis and contribute to sepsis complications. Platelets catalyse the development of hyperinflammation, disseminated intravascular coagulation and microthrombosis, and subsequently contribute to multiple organ failure. Inappropriate accumulation and activity of platelets are key events in the development of sepsis-related complications such as acute lung injury and acute kidney injury. Platelet activation readouts could serve as biomarkers for early sepsis recognition; inhibition of platelets in septic patients seems like an important target for immune-modulating therapy and appears promising based on animal models and retrospective human studies.

KEYWORDS:

Platelet immunology; infectious diseases; inflammatory mediators

PMID:
24966015
DOI:
10.1160/TH14-02-0126
[Indexed for MEDLINE]

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