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Eur J Obstet Gynecol Reprod Biol. 2014 Aug;179:187-90. doi: 10.1016/j.ejogrb.2014.05.039. Epub 2014 Jun 5.

Role of endometrial concentrations of heavy metals (cadmium, lead, mercury and arsenic) in the aetiology of unexplained infertility.

Author information

1
Medical Faculty, Inonu University, Malatya, Turkey.
2
Medical Faculty, Inonu University, Malatya, Turkey. Electronic address: drkaraer@yahoo.com.

Abstract

OBJECTIVE:

To determine the role of endometrial concentrations of heavy metals (cadmium, lead, mercury and arsenic) in the aetiology of unexplained infertility.

STUDY DESIGN:

Thirty-three women with unexplained infertility and 32 fertile women were recruited. Endometrial biopsies were collected during the putative window of implantation (cycle days 20-24). The concentrations of cadmium, lead, mercury and arsenic were measured in endometrial biopsy specimens using atomic absorption spectrometry.

RESULTS:

Cadmium was detected in 91% (30/33) of women with unexplained infertility, compared with 34% (11/32) of fertile women. The median endometrial cadmium concentration was 19.58 (interquartile range 1.46-30.23)μg/l in women with unexplained infertility, compared with 0.00 (interquartile range 0.00-0.40)μg/l in fertile women. Lead was detected in 15% (5/33) of women with unexplained infertility and 3% (1/32) of fertile women. Mercury and arsenic were not detected in any endometrial samples from either group.

CONCLUSION:

A significant difference in endometrial cadmium concentration was found between women with unexplained infertility and fertile women. This suggests that cadmium may be a contributing factor in the aetiology of unexplained infertility.

KEYWORDS:

Arsenic; Cadmium; Lead; Mercury; Unexplained infertility

PMID:
24966000
DOI:
10.1016/j.ejogrb.2014.05.039
[Indexed for MEDLINE]

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