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Mol Neurodegener. 2014 Jun 25;9:25. doi: 10.1186/1750-1326-9-25.

Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.

Author information

1
Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, SciencePark 904, 1098XH Amsterdam, The Netherlands. C.P.Fitzsimons@uva.nl.

Abstract

Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These control the expression of specific sets of genes, often including those encoding for small non-coding RNAs, indicating a complex interplay between various epigenetic factors and cellular functions.Previous studies had indicated that in addition to the neuropathology in Alzheimer's disease (AD), plasticity-related changes are observed in brain areas with ongoing neurogenesis, like the hippocampus and subventricular zone. Given the role of stem cells e.g. in hippocampal functions like cognition, and given their potential for brain repair, we here review the epigenetic mechanisms relevant for NSCs and AD etiology. Understanding the molecular mechanisms involved in the epigenetic regulation of adult NSCs will advance our knowledge on the role of adult neurogenesis in degeneration and possibly regeneration in the AD brain.

PMID:
24964731
PMCID:
PMC4080757
DOI:
10.1186/1750-1326-9-25
[Indexed for MEDLINE]
Free PMC Article

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