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Oncotarget. 2014 Jun 30;5(12):4320-36.

High nuclear level of Vav1 is a positive prognostic factor in early invasive breast tumors: a role in modulating genes related to the efficiency of metastatic process.

Author information

1
Section of Anatomy and Histology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy. These authors contributed equally to this work.
2
Department of Experimental and Clinical Sciences, University "G. d'Annunzio" Chieti, Italy. Center of Excellence for Research on Aging, Foundation University "G. d'Annunzio", Chieti, Italy.
3
Center of Excellence for Research on Aging, Foundation University "G. d'Annunzio", Chieti, Italy. Department of Biomorphology, University "G. D'Annunzio" Chieti, Italy.
4
''Regina Elena'' Cancer Institute, Rome, Italy.
5
Section of Anatomy and Histology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
6
CINBO Laboratories, University ''G. D'Annunzio'', Chieti, Italy.
7
Section of Anatomy and Histology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy. LTTA Centre, University of Ferrara, Ferrara, Italy.

Abstract

Vav1 is one of the signalling proteins normally restricted to hematopoietic cells that results ectopically expressed in solid tumors, including breast cancer. By immunohistochemical analysis on TMAs containing invasive breast tumor from patients without lymph node involvement, we have found that Vav1 is expressed in almost all investigated cancers and shows a peculiar localization inside the nucleus of tumor cells. High amounts of nuclear Vav1 are positively correlated with low incidence of relapse, regardless phenotype and molecular subtype of breast neoplasia. In particular, Kaplan-Meier plots showed an elevated risk of distant metastasis in patients with low Vav1 expression compared with patients with high Vav1 expression in their tumors. Experiments performed with breast tumor-derived cells indicated that Vav1 negatively modulates their invasiveness in vitro and their metastatic efficiency in vivo, possibly by affecting the expression of genes involved in invasion and/or metastasis of breast tumors. Since the high heterogeneity of breast tumors makes difficult to predict the evolution of early breast neoplasias, the evaluation of nuclear Vav1 levels may help in the characterization and management of early breast cancer patients. In particular, Vav1 may serve as a prognostic biomarker and a target for new therapies aimed to prevent breast cancer progression.

PMID:
24962430
PMCID:
PMC4147326
DOI:
10.18632/oncotarget.2011
[Indexed for MEDLINE]
Free PMC Article
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