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J Neural Transm. 1989;76(2):155-61.

A marked rise in 5-S-cysteinyl-dopamine levels in guinea-pig striatum following reserpine treatment.

Author information

1
Department of Pharmacology, University of Göteborg, Sweden.

Abstract

Reserpine administration (5 mg/kg, i.p.) to guinea pigs resulted in marked and long lasting dopamine (DA) depletion and a rapid, short lasting, increase of 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum. A marked and sustained increase of the level of 5-S-cysteinyl-dopamine, which is an adduct presumably formed following autoxidation of DA, started 3-4 h following the DA and DOPAC changes. Only small changes in the levels of the 5-S-cysteinyl adducts of DOPAC and 3,4-dihydroxyphenylalanine (DOPA) were found.

PMID:
2496196
DOI:
10.1007/bf01578755
[Indexed for MEDLINE]

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