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Development. 2014 Jul;141(13):2559-67. doi: 10.1242/dev.104588.

Heterogeneity and plasticity of epidermal stem cells.

Author information

1
BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen N DK-2200, Denmark.
2
Wellcome Trust & Medical Research Council Cambridge Stem Cell Institute, Tennis Court Road, Cambridge CB2 1QR, UK.
3
BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen N DK-2200, Denmark Wellcome Trust & Medical Research Council Cambridge Stem Cell Institute, Tennis Court Road, Cambridge CB2 1QR, UK kim.jensen@bric.ku.dk.

Abstract

The epidermis is an integral part of our largest organ, the skin, and protects us against the hostile environment. It is a highly dynamic tissue that, during normal steady-state conditions, undergoes constant turnover. Multiple stem cell populations residing in autonomously maintained compartments facilitate this task. In this Review, we discuss stem cell behaviour during normal tissue homeostasis, regeneration and disease within the pilosebaceous unit, an integral structure of the epidermis that is responsible for hair growth and lubrication of the epithelium. We provide an up-to-date view of the pilosebaceous unit, encompassing the heterogeneity and plasticity of multiple discrete stem cell populations that are strongly influenced by external cues to maintain their identity and function.

KEYWORDS:

Epidermis; Regeneration; Stem cells; Tissue homeostasis

PMID:
24961797
PMCID:
PMC4067958
DOI:
10.1242/dev.104588
[Indexed for MEDLINE]
Free PMC Article

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