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Sci Rep. 2014 Jun 25;4:5437. doi: 10.1038/srep05437.

Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice.

Author information

1
1] Immunity, Infection, and Inflammation Program, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Australia [2] King's College London, Institute of Pharmaceutical Science, London, SE1 9NH, UK [3] SAHMRI Infection and Immunity Theme, School of Medicine, Flinders University, Bedford Park, Adelaide, Australia.
2
King's College London, Institute of Pharmaceutical Science, London, SE1 9NH, UK.
3
Charles River UK, Manston Rd. Margate, Kent CT9 4LT UK.
4
Molecular Research MR DNA, Shallowater, TX 79363, USA.
5
Immunity, Infection, and Inflammation Program, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, Australia.

Abstract

Despite the fundamental contribution of the gut microbiota to host physiology, the extent of its variation in genetically-identical animals used in research is not known. We report significant divergence in both the composition and metabolism of gut microbiota in genetically-identical adult C57BL/6 mice housed in separate controlled units within a single commercial production facility. The reported divergence in gut microbiota has the potential to confound experimental studies using mammalian models.

PMID:
24961643
PMCID:
PMC4069701
DOI:
10.1038/srep05437
[Indexed for MEDLINE]
Free PMC Article

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