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Dev Cell. 2014 Jun 23;29(6):632-4. doi: 10.1016/j.devcel.2014.06.009.

Emerging from the clouds: Vasa helicase sheds light on piRNA amplification.

Author information

1
Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: julie.claycomb@utoronto.ca.

Abstract

Reporting in a recent study in Cell, Xiol and colleagues (2014) identify the conserved DEAD box helicase Vasa as a platform for secondary Piwi-interacting RNA (piRNA) biogenesis in the insect nuage. This study represents a substantial breakthrough in understanding the mechanism and location of piRNA amplification by the "ping-pong" cycle.

PMID:
24960691
DOI:
10.1016/j.devcel.2014.06.009
[Indexed for MEDLINE]
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