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Ren Fail. 2014 Jul;36(6):948-50. doi: 10.3109/0886022X.2014.917389.

A case of peritoneal TB causing renal failure in a patient with rheumatoid arthritis and initial negative PPD after treatment with infliximab.

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Department of Medicine, Maimonides Medical Center , NY , USA .


Opportunistic infection and reactivation of latent infection has been reported with use of monoclonal TNF alpha antibodies used for treatment of severe rheumatoid arthritis. We present a case of peritoneal tuberculosis (TB) causing renal failure secondary to ureteral constriction in a patient who had been treated with infliximab for rheumatoid arthritis. We suggest that physicians should be aware of the increased risk of false negative and false positive TST and IGRA among patients treated with monoclonal TNF alpha antibodies and should regularly look for usual and unusual symptoms of TB in this patient population.


Monoclonal TNF alpha antibodies; renal failure; tuberculosis

[Indexed for MEDLINE]

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