Send to

Choose Destination
J Int Neuropsychol Soc. 2014 Jul;20(6):588-98. doi: 10.1017/S1355617714000241. Epub 2014 Jun 24.

Reliability and validity of composite scores from the NIH Toolbox Cognition Battery in adults.

Author information

1Department of Psychiatry,University of California,San Diego,California.
2Departments of Rehabilitation Medicine,Orthopedic Surgery, and General Medicine,New York University Langone Medical Center,New York; and Spinal Cord Injury,Kessler Foundation,West Orange,New Jersey.
3Department of Neurology,University of California,Davis,California.
4Cognitive Neurology and Alzheimer's Disease Center and Department of Psychiatry and Behavioral Sciences,Northwestern Feinberg School of Medicine,Chicago,Illinois.
5Department of Rehabilitation Medicine,University of Washington,Seattle,Washington.
6Department of Medical Social Sciences,Northwestern University,Chicago,Illinois.
7San Diego State University/University of California,San Diego Joint Doctoral Program in Clinical Psychology,San Diego,California.
8National Institute on Drug Abuse,Rockville,Maryland.


This study describes psychometric properties of the NIH Toolbox Cognition Battery (NIHTB-CB) Composite Scores in an adult sample. The NIHTB-CB was designed for use in epidemiologic studies and clinical trials for ages 3 to 85. A total of 268 self-described healthy adults were recruited at four university-based sites, using stratified sampling guidelines to target demographic variability for age (20-85 years), gender, education, and ethnicity. The NIHTB-CB contains seven computer-based instruments assessing five cognitive sub-domains: Language, Executive Function, Episodic Memory, Processing Speed, and Working Memory. Participants completed the NIHTB-CB, corresponding gold standard validation measures selected to tap the same cognitive abilities, and sociodemographic questionnaires. Three Composite Scores were derived for both the NIHTB-CB and gold standard batteries: "Crystallized Cognition Composite," "Fluid Cognition Composite," and "Total Cognition Composite" scores. NIHTB Composite Scores showed acceptable internal consistency (Cronbach's alphas=0.84 Crystallized, 0.83 Fluid, 0.77 Total), excellent test-retest reliability (r: 0.86-0.92), strong convergent (r: 0.78-0.90) and discriminant (r: 0.19-0.39) validities versus gold standard composites, and expected age effects (r=0.18 crystallized, r=-0.68 fluid, r=-0.26 total). Significant relationships with self-reported prior school difficulties and current health status, employment, and presence of a disability provided evidence of external validity. The NIH Toolbox Cognition Battery Composite Scores have excellent reliability and validity, suggesting they can be used effectively in epidemiologic and clinical studies.

[Indexed for MEDLINE]
Free PMC Article

Publication type, MeSH terms, Grant support

Supplemental Content

Full text links

Icon for Cambridge University Press Icon for PubMed Central
Loading ...
Support Center