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Curr Opin Cell Biol. 2014 Oct;30:33-40. doi: 10.1016/j.ceb.2014.05.010. Epub 2014 Jun 22.

New paradigms in the establishment and maintenance of gradients during directed cell migration.

Author information

1
Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
2
IST Austria (Institute of Science and Technology Austria), 3400 Klostemeuburg, Austria.
3
Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address: parentc@mail.nih.gov.

Abstract

Directional guidance of migrating cells is relatively well explored in the reductionist setting of cell culture experiments. Here spatial gradients of chemical cues as well as gradients of mechanical substrate characteristics prove sufficient to attract single cells as well as their collectives. How such gradients present and act in the context of an organism is far less clear. Here we review recent advances in understanding how guidance cues emerge and operate in complex physiological settings.

PMID:
24959970
PMCID:
PMC4177954
DOI:
10.1016/j.ceb.2014.05.010
[Indexed for MEDLINE]
Free PMC Article
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