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Molecules. 2014 Jun 23;19(6):8544-55. doi: 10.3390/molecules19068544.

Loddigesiinols G-J: α-glucosidase inhibitors from Dendrobium loddigesii.

Author information

1
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. luyu0626@sina.com.
2
Guangdong Pharmaceutical University, Guangzhou 510006, China. kuangm55555@gmail.com.
3
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. huguping@mail.sysu.edu.cn.
4
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. wurb3@mail.sysu.edu.cn.
5
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. wjun@mail.sysu.edu.cn.
6
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. cesllan@mail.sysu.edu.cn.
7
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. ceslyc@mail.sysu.edu.cn.

Abstract

Four new polyphenols, loddigesiinols G-J (compounds 1-4) and a known compound, crepidatuol B (5), were isolated from the stems of Dendrobium loddigesii that have long been used in Traditional Chinese Medicine and have recently been used to treat type 2 diabetes. Compounds 1-5 structures were elucidated based on spectroscopic analysis. The absolute configurations of compounds 1-4 were determined using theoretical calculations of electronic circular dichroism (ECD), and the absolute configuration of compound 5 was determined by a comparison of the experimental ECD spectra and the literature data. Compounds 1-5 are strong inhibitors of α-glucosidase, with IC50 values of 16.7, 10.9, 2.7, 3.2, and 18.9 μM, respectively. Their activities were significantly stronger than trans-resveratrol as a positive control (IC50 values of 27.9 μM).

PMID:
24959681
DOI:
10.3390/molecules19068544
[Indexed for MEDLINE]
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