Format

Send to

Choose Destination
PLoS One. 2014 Jun 24;9(6):e100830. doi: 10.1371/journal.pone.0100830. eCollection 2014.

To achieve an earlier IFN-γ response is not sufficient to control Mycobacterium tuberculosis infection in mice.

Author information

1
Unitat de Tuberculosi Experimental (UTE), Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, CIBERES, Badalona, Catalonia, Spain.
2
Escola Superior d'Agricultura de Barcelona, Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, C/Esteve Terradas, Castelldefels, Catalonia, Spain.

Abstract

The temporo-spatial relationship between the three organs (lung, spleen and lymph node) involved during the initial stages of Mycobacterium tuberculosis infection has been poorly studied. As such, we performed an experimental study to evaluate the bacillary load in each organ after aerosol or intravenous infection and developed a mathematical approach using the data obtained in order to extract conclusions. The results showed that higher bacillary doses result in an earlier IFN-γ response, that a certain bacillary load (BL) needs to be reached to trigger the IFN-γ response, and that control of the BL is not immediate after onset of the IFN-γ response, which might be a consequence of the spatial dimension. This study may have an important impact when it comes to designing new vaccine candidates as it suggests that triggering an earlier IFN-γ response might not guarantee good infection control, and therefore that additional properties should be considered for these candidates.

PMID:
24959669
PMCID:
PMC4069189
DOI:
10.1371/journal.pone.0100830
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center