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Vaccine. 2014 Jul 31;32(35):4495-9. doi: 10.1016/j.vaccine.2014.06.042. Epub 2014 Jun 21.

Impact of 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) on childhood pneumonia hospitalizations in Brazil two years after introduction.

Author information

1
Centro Infant, Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga 6690, 2nd floor, Porto Alegre 90610-000, RS Brazil; Aliança Infant, Argentina-Brasil (Comprises partnership between institutions "a" and "c"). Electronic address: marcelo.scotta@acad.pucrs.br.
2
Jeser Amarante Faria Children's Hospital, Araranguá Street, 554, Joinville 89204-310, SC, Brazil. Electronic address: tnveras@hotmail.com.
3
Centro Infant, Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga 6690, 2nd floor, Porto Alegre 90610-000, RS Brazil. Electronic address: paulack@gmail.com.
4
Centro Infant, Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga 6690, 2nd floor, Porto Alegre 90610-000, RS Brazil. Electronic address: virginiatronco@yahoo.com.br.
5
Fundacion INFANT, Gavilán 94, (C1234BAA), Ciudad de Buenos Aires, Argentina; Vanderbilt University, 2201 West End Ave, Nashville 37235, TN, USA; Aliança Infant, Argentina-Brasil (Comprises partnership between institutions "a" and "c"). Electronic address: fernando.p.polack@vanderbilt.edu.
6
Centro Infant, Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga 6690, 2nd floor, Porto Alegre 90610-000, RS Brazil; Aliança Infant, Argentina-Brasil (Comprises partnership between institutions "a" and "c"). Electronic address: rita.mattiello@pucrs.br.
7
Centro Infant, Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga 6690, 2nd floor, Porto Alegre 90610-000, RS Brazil; Aliança Infant, Argentina-Brasil (Comprises partnership between institutions "a" and "c"). Electronic address: pmpitrez@pucrs.br.
8
Centro Infant, Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga 6690, 2nd floor, Porto Alegre 90610-000, RS Brazil; Aliança Infant, Argentina-Brasil (Comprises partnership between institutions "a" and "c"). Electronic address: mhjones@pucrs.br.
9
Centro Infant, Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga 6690, 2nd floor, Porto Alegre 90610-000, RS Brazil; Aliança Infant, Argentina-Brasil (Comprises partnership between institutions "a" and "c"). Electronic address: rstein@pucrs.br.
10
Centro Infant, Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga 6690, 2nd floor, Porto Alegre 90610-000, RS Brazil. Electronic address: leonardo.pinto@pucrs.br.

Abstract

INTRODUCTION:

Pneumococcal disease is a major public health problem worldwide. From March to September of 2010, 10-valent pneumococcal non-typeable Haemophilus influenzae protein conjugate vaccine (PHiD-CV) was introduced in the Brazilian childhood National Immunization Program (NIP) in all 27 Brazilian states. The aim of the present study is to report national time-trends in incidence of hospital admissions for childhood pneumonia in Brazil before and after two years of introduction of this new pneumococcal conjugate vaccine.

METHODS:

Analysis of hospitalization data of children aged 0-4 years in Brazilian public health system with an admission diagnosis of pneumonia from 2002 to 2012 was performed comparing pre (2002-2009) and post-vaccination periods (2011-2012). Hospital number of admission due to pneumonia and all non-respiratory diseases were obtained from DATASUS, the Brazilian government open-access public health database system. Incidence of pneumonia hospitalization was compared to incidence of all non-respiratory admissions.

RESULTS:

Admission rates for pneumonia decreased steadily from 2010 to 2012. In children aged less than four years, incidence of pneumonia hospitalizations decreased 12.65% when pre (2002-2009) and post-vaccination introduction periods (2011-2012) were compared and adjusted for seasonality and secular-trend (p<0.001). On the other hand, non-respiratory admission rates remained stable comparing both periods (p=0.39).

CONCLUSION:

Childhood pneumonia hospitalization rates were fluctuating prior to 2010 and decreased significantly in the two years after PHiD-CV introduction. Conversely, rate of non-respiratory admissions has shown no decrease. These data are an evidence of the effectiveness and public health impact of this new pneumococcal vaccine.

KEYWORDS:

Brazil; Child; Conjugate vaccines; Hospitalization; Pneumococcal vaccines; Pneumonia

PMID:
24958703
DOI:
10.1016/j.vaccine.2014.06.042
[Indexed for MEDLINE]

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