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Prostaglandins Leukot Essent Fatty Acids. 2014 Jul-Aug;91(1-2):49-60. doi: 10.1016/j.plefa.2014.04.004. Epub 2014 May 28.

Effect of supplementation with long-chain ω-3 polyunsaturated fatty acids on behavior and cognition in children with attention deficit/hyperactivity disorder (ADHD): a randomized placebo-controlled intervention trial.

Author information

1
Transfer Center for Neuroscience and Learning, University Hospital, Ulm, Germany; Department of Psychiatry, University Hospital, Ulm, Germany. Electronic address: katharina.widenhorn-mueller@uni-ulm.de.
2
SPZ, University Children׳s Hospital, Division of Social Pediatrics and Child Neurology, Ulm, Germany.
3
Transfer Center for Neuroscience and Learning, University Hospital, Ulm, Germany.
4
Transfer Center for Neuroscience and Learning, University Hospital, Ulm, Germany; Department of Psychiatry, University Hospital, Ulm, Germany.

Abstract

OBJECTIVE:

To determine whether supplementation with the long-chain omega-3 polyunsaturated fatty acids eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) affects behavioral symptoms and cognitive impairments in children 6-12 years of age diagnosed with attention-deficit/hyperactivity disorder (ADHD).

STUDY DESIGN:

The randomized, double-blind placebo-controlled 16 weeks trial was conducted with 95 children diagnosed with ADHD according to DSM-IV criteria. Behavior was assessed by parents, teachers and investigators using standardized rating scales and questionnaires. Further outcome variables were working memory, speed of information processing and various measures of attention. For a subgroup of 81 participants, erythrocyte membrane fatty acid composition was analyzed before and after the intervention.

RESULTS:

Supplementation with the omega-3 fatty acid mix increased EPA and DHA concentrations in erythrocyte membranes and improved working memory function, but had no effect on other cognitive measures and parent- and teacher-rated behavior in the study population. Improved working memory correlated significantly with increased EPA, DHA and decreased AA (arachidonic acid).

KEYWORDS:

Attention deficit/hyperactivity disorder (ADHD); Behavior; Children; Intervention; Polyunsaturated fatty acids/erythrocyte membrane composition; Working memory

PMID:
24958525
DOI:
10.1016/j.plefa.2014.04.004
[Indexed for MEDLINE]

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