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EMBO Rep. 2014 Aug;15(8):894-902. doi: 10.15252/embr.201438902. Epub 2014 Jun 23.

Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Author information

1
Department of Plant Biology, College of Biological Sciences University of California, Davis, CA, USA.
2
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.
3
Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
4
Department of Plant Biology, College of Biological Sciences University of California, Davis, CA, USA slharmer@ucdavis.edu.

Abstract

Chromatin regulatory proteins affect diverse developmental and environmental response pathways via their influence on nuclear processes such as the regulation of gene expression. Through a genome-wide genetic screen, we implicate a novel protein called X-chromosome-associated protein 5 (Xap5) in chromatin regulation. We show that Xap5 is a chromatin-associated protein acting in a similar manner as the histone variant H2A.Z to suppress expression of antisense and repeat element transcripts throughout the fission yeast genome. Xap5 is highly conserved across eukaryotes, and a plant homolog rescues xap5 mutant yeast. We propose that Xap5 likely functions as a chromatin regulator in diverse organisms.

KEYWORDS:

aberrant transcripts; chromatin modification; long terminal repeats; transcriptional repression; transposable elements

PMID:
24957674
PMCID:
PMC4197047
DOI:
10.15252/embr.201438902
[Indexed for MEDLINE]
Free PMC Article
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