Format

Send to

Choose Destination
Dev Med Child Neurol. 2014 Nov;56(11):1052-8. doi: 10.1111/dmcn.12512. Epub 2014 Jun 24.

Functional status at 18 months of age as a predictor of childhood disability after neonatal hypoxic-ischemic encephalopathy.

Collaborators (177)

Jobe AH, Caplan MS, Laptook AR, Oh W, Caskey M, Leach TM, Hensman AM, Leach TM, Noel L, Watson VE, Walsh MC, Fanaroff AA, Wilson-Costello DE, Bass N, Friedman HG, Newman NS, Siner BS, Schibler K, Donovan EF, Yolton K, Bridges K, Steichen JJ, Alexander B, Grisby C, Mincey HL, Hessling J, Gratton TL, Goldberg RN, Cotten CM, Gustafson KE, Goldstein RF, Auten KJ, Foy KA, Fisher KA, Grimes S, Lohmeyer MB, Stoll BJ, Carlton DP, Jain L, Adams-Chapman I, Blackwelder AM, Carter SL, Hale EC, Fritz S, LaRossa MM, Wright LL, McClure EM, Archer SW, Poindexter BB, Lemons JA, Dusick AM, Bissey J, Herron DE, Miller LC, Richard L, Wilson LD, Poole WK, Hammond JA, Auman JO, Cunningham M, Hastings BK, Newman JE, Huitema CM, Schaefer SE, Zaterka-Baxter KM, Van Meurs KP, Stevenson DK, Ball MB, DeAnda ME, Carlo WA, Ambalavanan N, Peralta-Carcelen M, Nelson KG, Collins MV, Cosby SS, Phillips VA, Smith LL, Finer NN, Kaegi D, Rasmussen MR, Vaucher YE, Fuller MG, West R, Arnell K, Henderson C, Rich W, Duara S, Bauer CR, Hiriart-Fajardo S, Allison M, Calejo M, Everett-Thomas R, Eguaras SM, Gauthier S, Mathews EE, Worth AM, Diaz AN, Gedeon YC, Hamlin-Smith K, Berkovits MH, Jean-Gilles L, Riguard A, Stoerger A, Pierre H, Garcia A, Laroia N, Guillet R, Phelps DL, Myers GJ, Markowitz GD, Reubens LJ, Hust D, Johnson JB, Burnell E, Jensen RL, Kushner E, Merzbach J, Yost K, Sánchez PJ, Rosenfeld CR, Salhab WA, Brion LP, Broyles RS, Heyne RJ, Adams SS, Boatman CT, Burchfield PJ, Dooley C, Guzman A, Heyne ET, Hickman JF, Leps MH, Madden LA, Miller NA, Vasil DM, Morgan JS, Madison S, Hensley G, Torres LE, Chen L, Tyson JE, Kennedy KA, Akpa EG, Cluff PA, Franco CI, Lis AE, McDavid GE, Tate PL, Alaniz NI, Bradt PJ, Cedillo M, Dieterich S, Evans PW, Green C, Jiminez M, Major-Kincade T, Morris BH, Poundstone ML, Reddoch S, Siddiki S, Simmons MC, Whitely LL, Wright SL, Valdés LM, Johnson YR, Bara R, Goldston LA, Muran G, Kennedy D, Pruitt PJ, Ehrenkranz RA, Gettner P, Konstantino M, Poulsen J, Romano E, Williams J, DeLancy S.

Author information

1
Department of Pediatrics, Wayne State University, Detroit, MI, USA.

Abstract

AIM:

In children with neonatal hypoxic-ischemic encephalopathy (HIE), we examined the association between 18-month functional status by parental report and disability at 6-7 years.

METHOD:

Prospective observational study involving participants in the NICHD randomized controlled trial of hypothermia for HIE. Parent questionnaires-Functional Status-II (FS-II), Impact on Family (IOF) and Family Resource Scale (FRS) at 18 months were correlated with 6- to 7-year developmental assessments. Disability at 6-7 years was defined as IQ < 70, gross motor functional classification scale level III-V, bilateral blindness, deafness, or epilepsy.

RESULTS:

Rates of severe HIE (32 vs. 15%), public insurance (73% vs. 47%) and IOF scales were higher and mean (SD) FS-II independence (I) {54 (SD 35) vs. 98 (SD 8)} and general health (GH) {87 (SD 14) vs. 98 (SD 6)} scores were significantly lower in children with disability (n=37) at 6-7 years, compared to those (n=74) without disability. FS-II I scores were significantly associated with disability (OR 0.92; 95% CI 0.87-0.97; p=0.003). On path analysis, severe HIE, greater IOF and public insurance were associated with poorer 18-month FS-II I scores, which, in turn, were associated with disability at 6 to 7 years.

INTERPRETATION:

Poor independent functioning by parental report at 18 months in children with HIE was associated with childhood disability.

PMID:
24957482
PMCID:
PMC4324462
DOI:
10.1111/dmcn.12512
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center