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Mol Cells. 2014 Jul;37(7):511-7. doi: 10.14348/molcells.2014.0132. Epub 2014 Jun 24.

Neuronal activity-dependent regulation of MicroRNAs.

Author information

1
Department of Brain and Cognitive Sciences, Seoul National University, Seoul 151-747, Korea.
2
Department of Brain and Cognitive Sciences, Seoul National University, Seoul 151-747, Korea ; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea.

Abstract

MicroRNAs are non-coding short (~23 nucleotides) RNAs that mediate post-transcriptional regulation through sequence-specific gene silencing. The role of miRNAs in neuronal development, synapse formation and synaptic plasticity has been highlighted. However, the role of neuronal activity on miRNA regulation has been less focused. Neuronal activity-dependent regulation of miRNA may fine-tune gene expression in response to synaptic plasticity and memory formation. Here, we provide an overview of miRNA regulation by neuronal activity including high-throughput screening studies. We also discuss the possible molecular mechanisms of activity-dependent induction and turnover of miRNAs.

KEYWORDS:

NMDAR; high-throughput screening; miRNA induction; miRNA turnover; neuronal activity

PMID:
24957213
PMCID:
PMC4132302
DOI:
10.14348/molcells.2014.0132
[Indexed for MEDLINE]
Free PMC Article

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