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J Altern Complement Med. 2014 Jul;20(7):578-9. doi: 10.1089/acm.2013.0216. Epub 2014 Jun 23.

Use of St. John's Wort in potentially dangerous combinations.

Author information

1
1 Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine , Winston-Salem, NC.

Abstract

OBJECTIVES:

The objective of this study was to assess how often St. John's wort (SJW) is prescribed with medications that may interact dangerously with it.

DESIGN:

The study design was a retrospective analysis of nationally representative data from the National Ambulatory Medical Care Survey.

SETTINGS:

The study setting was U.S. nonfederal outpatient physician offices.

SUBJECTS:

Those prescribed SJW between 1993 and 2010 were the subjects.

OUTCOME MEASURES:

The outcome measures were medications co-prescribed with SJW.

RESULTS:

Twenty-eight percent (28%) of SJW visits involved a drug that has potentially dangerous interaction with SJW. These included selective serotonin reuptake inhibitors, benzodiazepines, warfarin, statins, verapamil, digoxin, and oral contraceptives.

CONCLUSIONS:

SJW is frequently used in potentially dangerous combinations. Physicians should be aware of these common interactions and warn patients appropriately.

PMID:
24956073
DOI:
10.1089/acm.2013.0216
[Indexed for MEDLINE]

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