Format

Send to

Choose Destination
J Am Coll Nutr. 2014;33(3):231-8. doi: 10.1080/07315724.2013.869772.

Pigmented rice bran and plant sterol combination reduces serum lipids in overweight and obese adults.

Author information

1
a Nutritional Sciences (N.H.), and College of Public Health, Epidemiology and Biostatics (B.T.P.), University of Arizona , Tucson , Arizona ; Department of Food Nutrition and Health , University of British Columbia , Vancouver , British Columbia , CANADA (D.D.K., J.Z.); Department of Medicine, Clinical Research Center , Vanderbilt University , Nashville , Tennessee (C.M.D., M.S.B.); Department of Human Nutrition, Faculty of Food Technology , Agricultural University of Krakow , Krakow , POLAND (A.K.).

Abstract

OBJECTIVE:

This study investigated the dietary effect of including pigmented rice bran with or without plant sterols on lipid profiles during energy restriction-induced weight loss in overweight and obese adults not taking cholesterol-lowering medication. In addition, the study examined the effect of intervention on biomarkers of oxidative stress and inflammation.

METHODS:

A group of 24 overweight and obese adults (age: 43 ± 6 years, body mass index 32 ± 1 kg/m(2), 18 females) were randomized to a 25% calorie-restricted diet containing either pigmented rice bran (RB) or the RB with addition of plant sterols (RB+PS) snack bars for 8 weeks. The individualized nutrient-balanced diet contained ∼70% of daily energy needs assessed from indirect calorimetry measured resting energy expenditure (EE) and physical activity-related EE assessed using accelerometry. Anthropometrics, blood pressure, blood lipids, glucose, urinary F2-isoprostanes, C-reactive protein, insulin, and leptin were measured at baseline and after 8 weeks of intervention.

RESULTS:

Participants lost approximately 4.7 ± 2.2 kg (p < 0.001). Weight loss was not significant between the RB+PS and RB group (p = 0.056). Changes in body fat corresponded to changes in body weight. Average decrease in total cholesterol was significantly higher in the RB+PS group than in the RB group (difference 36 ± 25 g/dL vs 7 ± 16 g/dL; p = 0.044). A similar pattern was observed for the decrease in low-density lipoprotein (LDL) cholesterol (difference 22.3 ± 25.2 g/dL vs 4.4 ± 18.9 g/dL; p = 0.062). Changes in systolic blood pressure, serum levels of leptin, and F2-isoprostanes were significant between baseline values and after 8 weeks on the diet in both groups (p < 0.05) but did not differ between the 2 groups.

CONCLUSIONS:

A nutrient-balanced and energy-restricted diet supplemented with rice bran and plant sterols resulted in a significant decrease in total and LDL cholesterol in overweight and obese adults.

KEYWORDS:

bioactive compounds; clinical trials; diets; general nutrition; obesity; preventative nutrition and chronic disease; supplements and functional foods

PMID:
24955613
PMCID:
PMC4465497
DOI:
10.1080/07315724.2013.869772
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center