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Ann Clin Transl Neurol. 2014 May 1;1(5):370-374.

Preventable Infections in Children with Leukodystrophy.

Author information

1
School of Medicine, Salt Lake City, Utah.
2
Intermountain Healthcare (J.W., E.K.K.), Salt Lake City, Utah.
3
Division of Hematology and Hematological Malignancies (M.A.P.), Salt Lake City, Utah.
4
Division of Pediatric Infectious Diseases (A.J.B., A.L.H.), Salt Lake City, Utah.
5
Division of Inpatient Medicine (R.S.), Salt Lake City, Utah.
6
Division of Pediatric Neurology (J.L.B.), Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah ; Department of Neurology (J.L.B.), Salt Lake City, Utah.

Abstract

Children with inherited leukodystrophies have high hospitalization rates, often associated with infection. We studied whether potentially modifiable risk factors (pre-existing in-dwelling central intravenous access, urinary catheter, hardware, or mechanical ventilation; and influenza vaccine) were associated with infection-related hospitalization in children with leukodystrophy. Central intravenous access was associated with sepsis (odds ratio (OR) 9.8); urinary catheter was associated with urinary tract infections (OR 9.0); lack of seasonal vaccination was associated with influenza (OR 6.4); and mechanical ventilation was associated with pneumonia (OR 2.7). We conclude that potentially modifiable risk factors are significantly associated with infection and hospitalization in children with leukodystrophies.

KEYWORDS:

Leukodystrophy; bronchiolitis; infection; influenza; pneumonia; sepsis

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