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Ann Clin Transl Neurol. 2014 May 1;1(5):370-374.

Preventable Infections in Children with Leukodystrophy.

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School of Medicine, Salt Lake City, Utah.
Intermountain Healthcare (J.W., E.K.K.), Salt Lake City, Utah.
Division of Hematology and Hematological Malignancies (M.A.P.), Salt Lake City, Utah.
Division of Pediatric Infectious Diseases (A.J.B., A.L.H.), Salt Lake City, Utah.
Division of Inpatient Medicine (R.S.), Salt Lake City, Utah.
Division of Pediatric Neurology (J.L.B.), Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah ; Department of Neurology (J.L.B.), Salt Lake City, Utah.


Children with inherited leukodystrophies have high hospitalization rates, often associated with infection. We studied whether potentially modifiable risk factors (pre-existing in-dwelling central intravenous access, urinary catheter, hardware, or mechanical ventilation; and influenza vaccine) were associated with infection-related hospitalization in children with leukodystrophy. Central intravenous access was associated with sepsis (odds ratio (OR) 9.8); urinary catheter was associated with urinary tract infections (OR 9.0); lack of seasonal vaccination was associated with influenza (OR 6.4); and mechanical ventilation was associated with pneumonia (OR 2.7). We conclude that potentially modifiable risk factors are significantly associated with infection and hospitalization in children with leukodystrophies.


Leukodystrophy; bronchiolitis; infection; influenza; pneumonia; sepsis

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