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Biomed Res Int. 2014;2014:451781. doi: 10.1155/2014/451781. Epub 2014 May 14.

Bone marrow stem cells added to a hydroxyapatite scaffold result in better outcomes after surgical treatment of intertrochanteric hip fractures.

Author information

1
Faculty of Medicine, University of Porto, Alameda Hernani Monteiro, 4200-319 Porto, Portugal ; Hospital S. Joao, Alameda Professor HernĂ¢ni Monteiro, 4200-319 Porto, Portugal.
2
CEMUC, Faculdade de Engenharia, Universidade do Porto, Rua Doutor Roberto Frias, 4200-465 Porto, Portugal.
3
Hospital S. Joao, Alameda Professor HernĂ¢ni Monteiro, 4200-319 Porto, Portugal.
4
Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, 3471 Fifth Avenue, Kaufman building suite 1011, Pittsburgh, PA 15213, USA.

Abstract

INTRODUCTION:

Intertrochanteric hip fractures occur in the proximal femur. They are very common in the elderly and are responsible for high rates of morbidity and mortality. The authors hypothesized that adding an autologous bone marrow stem cells concentrate (ABMC) to a hydroxyapatite scaffold and placing it in the fracture site would improve the outcome after surgical fixation of intertrochanteric hip fractures.

MATERIAL AND METHODS:

30 patients were randomly selected and divided into 2 groups of 15 patients, to receive either the scaffold enriched with the ABMC (Group A) during the surgical procedure, or fracture fixation alone (Group B).

RESULTS:

There was a statistically significant difference in favor of group A at days 30, 60, and 90 for Harris Hip Scores (HHS), at days 30 and 60 for VAS pain scales, for bedridden period and time taken to start partial and total weight bearing (P < 0.05).

DISCUSSION:

These results show a significant benefit of adding a bone marrow enriched scaffold to surgical fixation in intertrochanteric hip fractures, which can significantly reduce the associated morbidity and mortality rates.

CONCLUSION:

Bone marrow stem cells added to a hydroxyapatite scaffold result in better outcomes after surgical treatment of intertrochanteric hip fractures.

PMID:
24955356
PMCID:
PMC4052697
DOI:
10.1155/2014/451781
[Indexed for MEDLINE]
Free PMC Article

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