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J Am Acad Child Adolesc Psychiatry. 2014 Jul;53(7):780-9.e11. doi: 10.1016/j.jaac.2014.05.003. Epub 2014 May 20.

Mapping the development of the basal ganglia in children with attention-deficit/hyperactivity disorder.

Author information

1
Behavioral Research Branch, National Human Genome Research Institute (NHGRI), and with the Intramural Program of the National Institute of Mental Health (NIMH). Electronic address: shawp@mail.nih.gov.
2
School of Medicine and Psychology, Sapienza University, Sant'Andrea Hospital, Rome, Italy.
3
Behavioral Research Branch, National Human Genome Research Institute (NHGRI), and with the Intramural Program of the National Institute of Mental Health (NIMH).
4
Child Psychiatry Branch at NIMH.
5
Behavioral Research Branch at NHGRI and the Intramural Program and Child Psychiatry Branch of NIMH.
6
Program in Neuroscience and Mental Health, The Hospital for Sick Children, Toronto, Canada.
7
Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada.

Abstract

OBJECTIVE:

The basal ganglia are implicated in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD), but little is known of their development in the disorder. Here, we mapped basal ganglia development from childhood into late adolescence using methods that define surface morphology with an exquisite level of spatial resolution.

METHOD:

Surface morphology of the basal ganglia was defined from neuroanatomic magnetic resonance images acquired in 270 youth with DSM-IV-defined ADHD and 270 age- and sex-matched typically developing controls; 220 individuals were scanned at least twice. Using linear mixed model regression, we mapped developmental trajectories from age 4 through 19 years at approximately 7,500 surface vertices in the striatum and globus pallidus.

RESULTS:

In the ventral striatal surfaces, there was a diagnostic difference in developmental trajectories (t = 5.6, p < .0001). Here, the typically developing group showed surface area expansion with age (estimated rate of increase of 0.54 mm(2) per year, standard error [SE] 0.29 mm(2) per year), whereas the ADHD group showed progressive contraction (decrease of 1.75 mm(2) per year, SE 0.28 mm(2) per year). The ADHD group also showed significant, fixed surface area reductions in dorsal striatal regions, which were detected in childhood at study entry and persisted into adolescence. There was no significant association between history of psychostimulant treatment and developmental trajectories.

CONCLUSIONS:

Progressive, atypical contraction of the ventral striatal surfaces characterizes ADHD, localizing to regions pivotal in reward processing. This contrasts with fixed, nonprogressive contraction of dorsal striatal surfaces in regions that support executive function and motor planning.

KEYWORDS:

attention-deficit/hyperactivity disorder; basal ganglia; development; neuroimaging; ventral striatum

PMID:
24954827
DOI:
10.1016/j.jaac.2014.05.003
[Indexed for MEDLINE]

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