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Structure. 2014 Jul 8;22(7):1063-70. doi: 10.1016/j.str.2014.05.005. Epub 2014 Jun 19.

Structure-based characterization of multiprotein complexes.

Author information

1
Division of Structural Biology & Bioinformatics, Department of Molecular Biology, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria. Electronic address: markII@came.sbg.ac.at.
2
Division of Structural Biology & Bioinformatics, Department of Molecular Biology, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria.
3
Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, 8320000 Santiago, Chile; Molecular Bioinformatics Laboratory, Millennium Institute on Immunology and Immunotherapy, 8320000 Santiago, Chile.

Abstract

Multiprotein complexes govern virtually all cellular processes. Their 3D structures provide important clues to their biological roles, especially through structural correlations among protein molecules and complexes. The detection of such correlations generally requires comprehensive searches in databases of known protein structures by means of appropriate structure-matching techniques. Here, we present a high-speed structure search engine capable of instantly matching large protein oligomers against the complete and up-to-date database of biologically functional assemblies of protein molecules. We use this tool to reveal unseen structural correlations on the level of protein quaternary structure and demonstrate its general usefulness for efficiently exploring complex structural relationships among known protein assemblies.

PMID:
24954616
PMCID:
PMC4087271
DOI:
10.1016/j.str.2014.05.005
[Indexed for MEDLINE]
Free PMC Article

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