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Clin Lung Cancer. 2014 Jul;15(4):249-57. doi: 10.1016/j.cllc.2014.04.008. Epub 2014 May 13.

Brain metastases in non-small-cell lung cancer.

Author information

1
Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: david.dawe@cancercare.mb.ca.
2
Department of Oncology, McMaster University, Hamilton, Ontario, Canada.

Abstract

Up to 50% of patients with advanced non-small-cell lung cancer will develop brain metastases at some point during their illness. These metastases cause a substantial burden in morbidity and mortality, which has motivated research and technological innovation over the past 2 decades. Surgery, radiotherapy, and systemic therapies have each played a role in management, with the greatest changes associated with the popularization of stereotactic radiosurgery. In this review, the evidence behind each modality used in the management of brain metastases for non-small-cell lung cancer patients is examined, and recommendations regarding the current standards of care and areas of future research focus are provided.

KEYWORDS:

Chemotherapy; Radiotherapy; Review; Stereotactic radiosurgery; Targeted agents

PMID:
24954227
DOI:
10.1016/j.cllc.2014.04.008
[Indexed for MEDLINE]

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