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Nat Rev Mol Cell Biol. 2014 Jul;15(7):433-52. doi: 10.1038/nrm3819.

Polo-like kinases: structural variations lead to multiple functions.

Author information

1
Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal.
2
1] Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal. [2] Laboratorio Nacional de Microscopía Avanzada, Instituto de Biotecnología, Universidad Nacional Autónoma de Mexico (UNAM), Avenida Universidad 2001, Col. Chamilpa, C.P. 62210 Cuernavaca Mor., Mexico.

Abstract

Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression, centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo major changes in abundance, activity, localization and structure at different stages of the cell cycle. They interact with other proteins in a tightly controlled spatiotemporal manner as part of a network that coordinates key cell cycle events. Their essential roles are highlighted by the fact that alterations in PLK function are associated with cancers and other diseases. Recent knowledge gained from PLK crystal structures, evolution and interacting molecules offers important insights into the mechanisms that underlie their regulation and activity, and suggests novel functions unrelated to cell cycle control for this family of kinases.

PMID:
24954208
DOI:
10.1038/nrm3819
[Indexed for MEDLINE]

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