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Parkinsonism Relat Disord. 2014 Sep;20(9):965-8. doi: 10.1016/j.parkreldis.2014.05.015. Epub 2014 Jun 10.

Psychiatric disturbances in patients with progressive supranuclear palsy: a case-control study.

Author information

1
Department of Neurology and Psychiatry, Sapienza University of Rome, Italy.
2
Department of Neurology and Psychiatry, Sapienza University of Rome, Italy; IRCSS Neuromed Institute, Pozzilli, IS, Italy.
3
Department of Neurology and Psychiatry, Sapienza University of Rome, Italy; IRCSS Neuromed Institute, Pozzilli, IS, Italy. Electronic address: giovanni.fabbrini@uniroma1.it.

Abstract

OBJECTIVES:

To investigate the frequency and the different types of psychiatric disturbances in PSP patients using validated psychiatric instruments.

METHODS:

We conducted a case-control study using the Structured Clinical Interview (SCID-I) for DSM-IV to investigate psychiatric disorders in 28 PSP patients and 28 age and gender matched healthy controls. PSP severity was scored using the PSP rating scale; cognitive functions were assessed using the Montreal Cognitive Assessment scale and the Frontal Assessment Battery scale.

RESULTS:

SCID-I disclosed that psychiatric disturbances were more frequent in PSP patients (53%) than in healthy controls (17.8%) (p = 0.005). Psychiatric disorders in PSP patients were characterized by mood disorders. Depression due to PSP was the most frequent diagnosis and was found in 8 of the 15 patients with depressive disorders. None of the PSP patients had a diagnosis of other SCID-I disorders. No clinical or demographic differences were found when comparing PSP patients with and without psychiatric disturbances.

CONCLUSIONS:

Psychiatric disturbances, namely depressive disorders, were more frequent in PSP patients than in controls. A thorough evaluation of psychiatric disorders is important to insure appropriate treatment of PSP patients..

KEYWORDS:

Anxiety; Depression; Progressive supranuclear palsy; SCID-I

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