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Dev Cell. 2014 Jul 14;30(1):103-9. doi: 10.1016/j.devcel.2014.05.003. Epub 2014 Jun 19.

Independent genomic control of neuronal number across retinal cell types.

Author information

1
Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA; Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
2
Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
3
Center of Genomics and Bioinformatics, University of Tennessee Health Science Center, Memphis, TN 38120, USA; Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38120, USA.
4
Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA; Department of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. Electronic address: breese@psych.ucsb.edu.

Abstract

The sizes of different neuronal populations within the CNS are precisely controlled, but whether neuronal number is coordinated between cell types is unknown. We examined the covariance structure of 12 different retinal cell types across 30 genetically distinct lines of mice, finding minimal covariation when comparing synaptically connected or developmentally related cell types. Variation mapped to one or more genomic loci for each cell type, but rarely were these shared, indicating minimal genetic coregulation of final number. Multiple genes, therefore, participate in the specification of the size of every population of retinal neuron, yet genetic variants work largely independent of one another during development to modulate those numbers, yielding substantial variability in the convergence ratios between pre- and postsynaptic populations. Density-dependent cellular interactions in the outer plexiform layer overcome this variability to ensure the formation of neuronal circuits that maintain constant retinal coverage and complete afferent sampling.

PMID:
24954025
PMCID:
PMC4101151
DOI:
10.1016/j.devcel.2014.05.003
[Indexed for MEDLINE]
Free PMC Article
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