Manzamine alkaloids: isolation, cytotoxicity, antimalarial activity and SAR studies

Drug Discov Today. 2014 Nov;19(11):1781-1791. doi: 10.1016/j.drudis.2014.06.010. Epub 2014 Jun 20.

Abstract

The infectious disease Malaria is caused by different species of the genus Plasmodium. Resistance to quinoline antimalarial drugs and decreased susceptibility to artemisinin-based combination therapy have increased the need for novel antimalarial agents. Historically, natural products have been used for the treatment of infectious diseases. Identification of natural products and their semi-synthetic derivatives with potent antimalarial activity is an important method for developing novel antimalarial agents. Manzamine alkaloids are a unique group of β-carboline alkaloids isolated from various species of marine sponge displaying potent antimalarial activity against drug-sensitive and -resistant strains of Plasmodium. In this review, we demonstrate antimalarial potency, cytotoxicity and antimalarial SAR of manzamine alkaloids.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antimalarials* / chemistry
  • Antimalarials* / isolation & purification
  • Antimalarials* / pharmacology
  • Antimalarials* / therapeutic use
  • Carbazoles* / chemistry
  • Carbazoles* / isolation & purification
  • Carbazoles* / pharmacology
  • Carbazoles* / therapeutic use
  • Humans
  • Indole Alkaloids* / chemistry
  • Indole Alkaloids* / isolation & purification
  • Indole Alkaloids* / pharmacology
  • Indole Alkaloids* / therapeutic use
  • Plasmodium / drug effects
  • Structure-Activity Relationship

Substances

  • Antimalarials
  • Carbazoles
  • Indole Alkaloids