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Indian Pediatr. 2014 May;51(5):359-65.

INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD): development and validation.

Author information

1
INCLEN Trust International, New Delhi, India. Correspondence to: Dr Narendra K Arora, Executive Director, The INCLEN TRUST International, F1/5, Okhla Industrial Area, Phase-1, New Delhi, India. nkarora@inclentrust.org.

Abstract

OBJECTIVE:

To develop and validate INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD).

DESIGN:

Diagnostic test evaluation by cross sectional design.

SETTING:

Four tertiary pediatric neurology centers in Delhi and Thiruvanthapuram, India.

METHODS:

Children aged 2-9 years were enrolled in the study. INDT-ASD and Childhood Autism Rating Scale (CARS) were administered in a randomly decided sequence by trained psychologist, followed by an expert evaluation by DSM-IV TR diagnostic criteria (gold standard).

MAIN OUTCOME MEASURES:

Psychometric parameters of diagnostic accuracy, validity (construct, criterion and convergent) and internal consistency.

RESULTS:

154 children (110 boys, mean age 64.2 mo) were enrolled. The overall diagnostic accuracy (AUC=0.97, 95% CI 0.93, 0.99; P<0.001) and validity (sensitivity 98%, specificity 95%, positive predictive value 91%, negative predictive value 99%) of INDT-ASD for Autism spectrum disorder were high, taking expert diagnosis using DSM-IV-TR as gold standard. The concordance rate between the INDT-ASD and expert diagnosis for 'ASD group' was 82.52% [Cohen's k=0.89; 95% CI (0.82, 0.97); P=0.001]. The internal consistency of INDT-ASD was 0.96. The convergent validity with CARS (r = 0.73, P= 0.001) and divergent validity with Binet-Kamat Test of intelligence (r = -0.37; P=0.004) were significantly high. INDT-ASD has a 4-factor structure explaining 85.3% of the variance.

CONCLUSIONS:

INDT-ASD has high diagnostic accuracy, adequate content validity, good internal consistency high criterion validity and high to moderate convergent validity and 4-factor construct validity for diagnosis of Autistm spectrum disorder.

PMID:
24953575
[Indexed for MEDLINE]
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