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Int J Geriatr Psychiatry. 2015 May;30(5):470-7. doi: 10.1002/gps.4161. Epub 2014 Jun 20.

Apathy as a feature of prodromal Alzheimer's disease: an FDG-PET ADNI study.

Author information

1
Alzheimer's Disease Clinical Research Centre, Gérontopôle, Toulouse University Hospital, Toulouse, France.

Abstract

OBJECTIVE:

The goal of this study is to evaluate brain metabolism in mild cognitive impairment (MCI) patients with and without apathy (as determined by the Neuropsychiatric Inventory Questionnaire).

METHODS:

Baseline data from 65 MCI participants (11 with apathy and 54 without) from the Alzheimer's Disease (AD) Neuroimaging Initiative study were analyzed. All participants underwent a comprehensive cognitive and neuropsychiatric assessment, volumetric MRI and measures of cerebral glucose metabolism applying (18)F-fluorodeoxyglucose positron emission tomography at baseline. The presence of apathy at baseline was determined by the Neuropsychiatric Inventory Questionnaire.

RESULTS:

There was no difference between apathy and apathy-free MCI patients regarding cognitive assessment and neuropsychiatric measures when apathy-specific items were removed. Cerebrovascular disease load and cerebral atrophy were equivalent in both groups. Compared with the apathy-free MCI patients, MCI patients with apathy had significantly decreased metabolism in the posterior cingulate cortex.

CONCLUSION:

The presence of apathy in MCI patients is associated with AD-specific pattern of brain metabolic defect. These results could suggest that apathy belongs to the spectrum of prodromal AD symptoms.

KEYWORDS:

Alzheimer's disease; Alzheimer's disease neuroimaging initiative (ADNI); FDG-PET; apathy; biomarker; mild cognitive impairment

PMID:
24953008
DOI:
10.1002/gps.4161
[Indexed for MEDLINE]

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