Format

Send to

Choose Destination
Mol Cell Endocrinol. 2014 Nov;397(1-2):15-22. doi: 10.1016/j.mce.2014.06.005. Epub 2014 Jun 18.

Hypothalamic inflammation and the central nervous system control of energy homeostasis.

Author information

1
Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
2
Cardiovascular Research Institute, University of California, San Francisco, CA 94158-9001, United States.
3
Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. Electronic address: carvalheira@me.com.

Abstract

The control of energy homeostasis relies on robust neuronal circuits that regulate food intake and energy expenditure. Although the physiology of these circuits is well understood, the molecular and cellular response of this program to chronic diseases is still largely unclear. Hypothalamic inflammation has emerged as a major driver of energy homeostasis dysfunction in both obesity and anorexia. Importantly, this inflammation disrupts the action of metabolic signals promoting anabolism or supporting catabolism. In this review, we address the evidence that favors hypothalamic inflammation as a factor that resets energy homeostasis in pathological states.

KEYWORDS:

Cancer; Cytokines; Hypothalamus; Inflammation; Obesity; Peripheral tissues

PMID:
24952114
DOI:
10.1016/j.mce.2014.06.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center