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Maturitas. 2014 Aug;78(4):263-76. doi: 10.1016/j.maturitas.2014.05.007. Epub 2014 May 28.

Effects of isoflavones and amino acid therapies for hot flashes and co-occurring symptoms during the menopausal transition and early postmenopause: a systematic review.

Author information

1
University of Washington School of Nursing, United States. Electronic address: ajthomas@uw.edu.
2
University of Washington School of Nursing, United States and Ministry of Health, Republic of Indonesia, United States.
3
University of Washington School of Nursing, United States.
4
College of Nursing, Seattle University, United States.
5
Health Sciences Library, University of Washington, United States.
6
Family and Child Nursing, University of Washington, United States.
7
Biobehavioral Nursing and Health Systems, University of Washington, United States.

Abstract

AIMS:

Review controlled clinical trials of isoflavones and amino acid preparation effects on hot flashes and at least one other symptom including mood, sleep, pain, and cognitive function that women report during the menopausal transition and early postmenopause.

METHODS:

An experienced reference librarian searched PubMed/Medline, CINAHL Plus, PsycInfo, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Web of Science, EMBASE, AMED, and Alt-Health Watch for English-language randomized controlled trials between 2004 and July 2011. Seventeen trials of isoflavones and amino acid effects on hot flashes and one additional symptom were identified.

RESULTS:

In five trials of soy isoflavone preparations, two (6g soy germ extract and 25 g soy protein in soy nuts) significantly decreased hot flashes, but no other symptoms. In the seven trials of other isoflavones, six significantly reduced hot flashes; in addition, red clover (80 mg) significantly reduced mood symptoms; Rexflavone (350 mg) for women with Kupperman Index>20 significantly reduced sleep symptoms; two trials had significant reductions for pain: isoflavone powder (90 mg) and red clover (80 mg). The only trial in this systematic review that significantly reduced cognitive symptoms was red clover (80 mg). In one trial, red clover isoflavone (80 mg/day) significantly relieved hot flashes, mood, pain, and cognitive symptoms. Amino acids yielded no significant results. Equol supplements of 30 mg/day for non-Equol producing women significantly reduced mood symptoms in one trial. The magnolia bark extract combination significantly reduced hot flashes, mood, and sleep symptoms.

CONCLUSIONS:

Isoflavone trials yielded significant reductions on hot flashes and co-occurring symptoms during the menopausal transition and postmenopause, but studies require replication with larger sample sizes and attention to measurement of outcomes.

KEYWORDS:

Amino acids; Hot flashes; Isoflavones; Menopausal transition; Soy; Symptom clusters

PMID:
24951101
PMCID:
PMC4120238
DOI:
10.1016/j.maturitas.2014.05.007
[Indexed for MEDLINE]
Free PMC Article

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