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Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Sep;118(3):309-19. doi: 10.1016/j.oooo.2014.04.008. Epub 2014 May 6.

Validation of the diagnostic utility of salivary interleukin 8 in the differentiation of potentially malignant oral lesions and oral squamous cell carcinoma in a region with high endemicity.

Author information

1
Professor and Head, Department of Oral and Maxillofacial Pathology, SRM Dental College, SRM University, Chennai, Tamil Nadu, India. Electronic address: drrajkumar22163@yahoo.co.uk.
2
Assistant Professor, Department of Oral and Maxillofacial Pathology, SRM Dental College, SRM University, Chennai, Tamil Nadu, India.
3
Associate Professor, Department of Oral and Maxillofacial Pathology, SRM Dental College, SRM University, Chennai, Tamil Nadu, India.
4
Research Faculty, Department of Oral and Maxillofacial Pathology, SRM Dental College, SRM University, Chennai, Tamil Nadu, India.
5
Professor, Department of Oral and Maxillofacial Pathology, SRM Dental College, SRM University, Chennai, Tamil Nadu, India.
6
Professor, Department of Biochemistry, SRM Dental College, SRM University, Chennai, Tamil Nadu, India.

Abstract

OBJECTIVE:

To evaluate the clinical utility of salivary interleukin 8 (IL-8) in the differential diagnosis of potentially malignant lesions (PMLs) and oral squamous cell carcinoma (OSCC) in a region with high oral cancer prevalence.

STUDY DESIGN:

Saliva and blood samples were collected from 100 participants in each group (OSCC, PMLs, and healthy controls). Serum and salivary IL-8 levels were measured by enzyme-linked immunosorbent assay. The data were subjected to appropriate statistical analysis.

RESULTS:

A significant increase in levels of serum and salivary IL-8 was found in OSCC compared with PMLs and healthy controls. Receiver operating characteristic curve analysis found salivary IL-8 to have superior sensitivity in detecting OSCC. A significant increase in IL-8 levels based on the histologic grading of OSCC was also observed.

CONCLUSIONS:

This study confirms that salivary IL-8 can be a potent marker that can be used as a tool in the differential diagnosis of PMLs and OSCC.

PMID:
24950604
DOI:
10.1016/j.oooo.2014.04.008
[Indexed for MEDLINE]

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