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Genet Test Mol Biomarkers. 2014 Aug;18(8):580-6. doi: 10.1089/gtmb.2014.0102. Epub 2014 Jun 20.

Diagnostic significance of serum osteopontin level for pancreatic cancer: a meta-analysis.

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1
1 Department of Radiotherapy, The First Affiliated Hospital, China Medical University , Shenyang, People's Republic of China .

Abstract

OBJECTIVE:

This meta-analysis aimed to identify the significance of serum osteopontin (OPN) level for the diagnosis of pancreatic cancer (PC).

METHODS:

Through searching the following electronic databases-the Cochrane Library Database (Issue 12, 2013), Web of Science (1945-2013), PubMed (1966-2013), CINAHL (1982-2013), EMBASE (1980-2013), and the Chinese Biomedical Database (CBM) (1982-2013)-related articles were determined without any language restrictions. The STATA statistical software (version 12.0; Stata Corporation, College Station, TX) was chosen to deal with statistical data. Standard mean difference (SMD) and its corresponding 95% confidence interval (95% CI) was calculated. Eleven clinical case-control studies, which recruited 491 PC patients and 481 healthy controls, were selected for statistical analysis.

RESULTS:

Combined SMD of OPN suggested that the serum OPN level in PC patients was significantly higher than that in healthy controls (SMD=3.58, 95% CI=2.42-4.74, p<0.001). Ethnicity stratified analysis indicated a higher serum OPN level in PC patients compared with control subjects among both Caucasians and Asians (Caucasians: SMD=2.62, 95% CI=1.33-3.91, p<0.001; Asians: SMD=4.54, 95% CI=2.80-6.27, p<0.001; respectively).

CONCLUSION:

The main finding of our meta-analysis revealed that an elevated serum OPN level may be used as a promising diagnostic tool for early identification of PC.

PMID:
24950303
DOI:
10.1089/gtmb.2014.0102
[Indexed for MEDLINE]
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