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Arch Biochem Biophys. 2014 Sep 15;558:10-3. doi: 10.1016/j.abb.2014.05.028. Epub 2014 Jun 17.

Neurogenins in brain development and disease: an overview.

Author information

1
VIB Center for the Biology of Disease, VIB, 3000 Leuven, Belgium; Center for Human Genetics, University of Leuven School of Medicine, 3000 Leuven, Belgium.
2
VIB Center for the Biology of Disease, VIB, 3000 Leuven, Belgium; Center for Human Genetics, University of Leuven School of Medicine, 3000 Leuven, Belgium. Electronic address: bh@kuleuven.be.

Abstract

The production of neurons, astrocytes and oligodendrocytes is regulated by a group of transcription factors, which determine cell fates and specify subtype identities in the nervous system. Here we focus on profiling the distinct roles of Neurogenin (Ngn or Neurog) family members during the neuronal development. Ngn proteins are tightly regulated to be expressed at defined times and positions of different progenitor cell pools. In addition to their well-elucidated proneural function, Ngn proteins play various critical roles to specify or maintain cell fate and regulate neurite outgrowth and targeting in the central nervous system. Finally, Ngns have been associated with neuronal disorders. Therefore understanding the function and regulation of Ngns will not only improve the understanding of the molecular mechanism underlying the development of nervous system, but may also provide insight into neuronal disease.

KEYWORDS:

Anti-glia; Axon guidance; Dendrite morphology; Gliogenesis; Neurogenin; Proneural gene; bHLH protein

PMID:
24950022
DOI:
10.1016/j.abb.2014.05.028
[Indexed for MEDLINE]
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