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Cell. 2014 Jun 19;157(7):1500-1. doi: 10.1016/j.cell.2014.06.009.

Shedding "UV" light on endogenous opioid dependence.

Author information

1
Synaptic Plasticity Section, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, Baltimore, MD 21224, USA.
2
Synaptic Plasticity Section, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, Baltimore, MD 21224, USA. Electronic address: antonello.bonci@nih.gov.

Abstract

Excessive sun tanning can result in addictive behavior. In this issue of Cell, Fell et al. utilize a combination of behavioral pharmacology and transgenic mice to demonstrate that chronic UV light exposure recruits p53 signaling in keratinocytes, subsequently increasing β-endorphin signaling at opioid receptors, and produces an endogenous opioid-dependent state.

PMID:
24949960
DOI:
10.1016/j.cell.2014.06.009
[Indexed for MEDLINE]
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