Format

Send to

Choose Destination
Antioxid Redox Signal. 2014 Oct 10;21(11):1648-59. doi: 10.1089/ars.2014.6000. Epub 2014 Sep 4.

Metabolic regulation of redox status in stem cells.

Author information

1
Center for Regenerative Medicine, Mayo Clinic , Rochester, Minnesota.

Abstract

SIGNIFICANCE:

Metabolism-dependent generation of reactive oxygen species (ROS) and associated oxidative damage have been traditionally linked to impaired homeostasis and cellular death. Beyond the adverse effects of ROS accumulation, increasing evidence implicates redox status as a regulator of vital cellular processes.

RECENT ADVANCES:

Emerging studies on the molecular mechanisms guiding stem cell fate decisions indicate a role for energy metabolism in regulating the fundamental ability of maintaining stemness versus undergoing lineage-specific differentiation. Stem cells have evolved protective metabolic phenotypes to minimize reactive oxygen generation through oxidative metabolism and support antioxidant scavenging through glycolysis and the pentose phosphate pathway.

CRITICAL ISSUES:

While the dynamics in ROS generation has been correlated with stem cell function, the intimate mechanisms by which energy metabolism regulates ROS to impact cellular fate remain to be deciphered.

FUTURE DIRECTIONS:

Decoding the linkage between nutrient sensing, energy metabolism, and ROS in regulating cell fate decisions would offer a redox-dependent strategy to regulate stemness and lineage specification.

PMID:
24949895
PMCID:
PMC4174422
DOI:
10.1089/ars.2014.6000
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center