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Biosens Bioelectron. 2014 Nov 15;61:491-9. doi: 10.1016/j.bios.2014.05.039. Epub 2014 Jun 3.

Brief review of monitoring methods for loop-mediated isothermal amplification (LAMP).

Author information

1
Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of Agriculture, Qingdao 266071, PR China. Electronic address: zhangxz@ysfri.ac.cn.
2
School of Chemistry and Australian Centre for NanoMedicine, The University of New South Wales, Sydney, NSW 2052, Australia.
3
School of Chemistry and Australian Centre for NanoMedicine, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: justin.gooding@unsw.edu.au.

Abstract

The loop-mediated isothermal amplification (LAMP) technique has the potential to revolutionize molecular biology because it allows DNA amplification under isothermal conditions and is highly compatible with point-of-care analysis. To achieve efficient genetic analysis of samples, the method of real-time or endpoint determination selected to monitor the biochemical reaction is of great importance. In this paper we briefly review progress in the development of monitoring methods for LAMP.

KEYWORDS:

Biosensor; LAMP; Loop-mediated isothermal amplification; Monitoring methods; Point-of-care analysis

PMID:
24949822
DOI:
10.1016/j.bios.2014.05.039
[Indexed for MEDLINE]

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