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Endosc Ultrasound. 2012 Apr;1(1):17-22. doi: 10.7178/eus.01.004.

Endoscopic ultrasound-guided fine needle aspiration cytology and biopsy in the evaluation of lymphoma.

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Gastroenterology Department, University Hospital of Canary Islands, La Laguna, Tenerife, Spain.
Internal Medicine Department, Gastroenterology Unit, Alhossien Hospital, Alazhar University, Cairo, Egypt.
Gastroenterology Department, Saint Luc Hospital, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.


Accurate diagnosis and subtyping of lymphoma have important prognostic implications and are generally required for treatment planning. Histological assessment, immunophenotyping, and genetic studies are usually necessary. Endoscopic ultrasound guided-fine needle aspiration cytology (EUS-FNAC) is a minimally invasive technique widely used for the evaluation of deep-seated benign and malignant lesions. However, the value of cytological samples in lymphoma diagnosis is still a matter of debate. Endoscopic ultrasound guided-fine needle biopsy (EUS-FNAB) can provide tissue core samples that may help overcome the limitations of cytology. The aim of this review is to summarize the available literature regarding EUS-FNAC and EUS-FNAB for the diagnosis and subtyping of lymphoma. In addition, we discuss its usefulness in the management of primary extra-nodal lymphomas, as well as technical issues that may influence sample quality.


biopsy; cytology; endoscopic ultrasound; fine needle aspiration; lymphoma

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