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Magn Reson Med. 2015 Jun;73(6):2262-73. doi: 10.1002/mrm.25334. Epub 2014 Jun 19.

Esophageal carcinoma: Evaluation with q-space diffusion-weighted MR imaging ex vivo.

Author information

1
Department of Diagnostic Radiology and Oncology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
2
Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
3
Central Institute for Experimental Animals, Kanagawa, Japan.
4
Department of Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
5
Department of Esophagogastric Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
6
Department of Pathology, Tokyo Medical and Dental University, Tokyo, Japan.

Abstract

PURPOSE:

To determine the usefulness of q-space MR imaging as means of evaluating the depth of mural invasion, the histologic grades, and lymph node metastasis in esophageal carcinomas.

METHODS:

Twenty esophageal specimens each containing a carcinoma were studied with a 7.0 Tesla MR imaging system. q-Space MR images were obtained with a 50-60 mm × 25-30 mm field of view, 256 × 128 matrix, 2 mm section thickness, 10 b values ranging from 0 to 7163 s/mm(2) , and a motion-probing gradient in the y-direction, and the MR images were compared with the histopathologic findings.

RESULTS:

The mean displacement maps, probability for zero displacement maps, and kurtosis maps in all 20 carcinomas (100%) made it possible to identify the depth of tumor invasion of the esophageal wall. These q-space MR imaging parameters were significantly correlated with the histologic grades of the esophageal carcinomas (P < 0.01), and also significantly correlated with their nuclear-cytoplasmic ratios (P < 0.01 or P < 0.001) and tumor cellularity (cell density) (P < 0.01 or P < 0.001). The q-space MR imaging parameters were also capable of differentiating between the metastatic lymph nodes and nonmetastatic lymph nodes (P < 0.01).

CONCLUSION:

q-Space MR imaging ex vivo provides excellent diagnostic accuracy for evaluating mural invasion by esophageal carcinomas, the histologic grades of esophageal carcinomas, and lymph node metastasis by esophageal carcinomas.

KEYWORDS:

MR imaging; diffusion-weighted imaging; esophageal carcinoma; esophagus; q-space imaging

PMID:
24947492
DOI:
10.1002/mrm.25334
[Indexed for MEDLINE]

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