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Trends Microbiol. 2014 Oct;22(10):559-65. doi: 10.1016/j.tim.2014.05.006. Epub 2014 Jun 16.

Bacterial (intramembrane-sensing) histidine kinases: signal transfer rather than stimulus perception.

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Ludwig-Maximilians-Universität München, Department of Biology I, Microbiology, Grosshaderner Strasse 2-4, 82152 Planegg-Martinsried, Germany. Electronic address:


Most membrane-anchored histidine kinases (HKs) of bacterial two-component systems (2CSs) contain an extracellular input domain that is thought to be responsible for sensing an environmental cue. By contrast, intramembrane-sensing HKs (IM-HKs) lack a sensory domain and cannot perceive their stimuli directly. Instead, an N-terminal signal transfer region, consisting solely of two transmembrane helices, presumably connects the IM-HKs with accessory membrane proteins that function as the true sensors. This intermolecular signal transfer, in combination with intramolecular signal conversion, provides HKs with versatile signaling relays to connect, integrate, and amplify external signals from different sensory inputs ultimately to modulate the activity of the corresponding kinase domain.


histidine kinase; signal transduction; stimulus perception; two-component system

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