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Reprod Toxicol. 2014 Aug;47:70-6. doi: 10.1016/j.reprotox.2014.06.002. Epub 2014 Jun 16.

Prenatal and peripubertal phthalates and bisphenol A in relation to sex hormones and puberty in boys.

Author information

1
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA.
2
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA; Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
3
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA; Child Health Evaluation and Research Unit, University of Michigan, Ann Arbor, MI, USA; Pediatric Endocrinology, University of Michigan, Ann Arbor, MI, USA.
4
Division of Statistics, Center for Evaluation Research and Surveys, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
5
American British Chowdray (ABC) Hospital, México City, Mexico.
6
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA. Electronic address: meekerj@umich.edu.

Abstract

Phthalates and BPA are known endocrine disruptors and exposure in pregnant mothers and children is ubiquitous. We explored the relationship of prenatal and childhood exposures with pubertal onset and sex hormones in boys (ages 8-14). Phthalate metabolites and BPA were measured in maternal 3rd trimester or childhood urine. Sex hormones DHEAS, estradiol, inhibin B, SHBG, and total testosterone were measured in serum. Adrenarche and puberty were assessed by pediatrician. Prenatal exposure to some phthalates was associated with decreased DHEAS and inhibin B levels, and with increased SHBG. Prenatal exposure to most phthalates and BPA was associated with greatly reduced odds of adrenarche (odds ratios [OR]=0.12-0.65) and slightly reduced odds of puberty (OR=0.50-0.98). Childhood exposure was not associated with adrenarche or puberty, but some phthalates and BPA were associated with increased SHBG levels and decreased total and free testosterone levels.

KEYWORDS:

Bisphenol A; Environment; Exposure; Puberty; Tanner stage; Testosterone

PMID:
24945889
PMCID:
PMC4117729
DOI:
10.1016/j.reprotox.2014.06.002
[Indexed for MEDLINE]
Free PMC Article

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