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Nat Prod Res. 2014;28(13):960-6. doi: 10.1080/14786419.2014.900771. Epub 2014 Jun 19.

A new flavonol glycoside from the medicinal halophyte Suaeda fruticosa.

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a Laboratoire des Plantes Extrêmophiles, Centre de Biotechnologie à la Technopôle de Borj-Cédria (CBBC) , BP 901, 2050 Hammam-Lif , Tunisia.


A new flavonol glycoside, namely 3-(α-rhamnopyranosyl-(1 → 2)-[β-xylopyranosyl-(1 → 6)]-β-glucopyranosyloxy) isorhamnetin was reported from methanol extracts of aerial parts of Suaeda fruticosa for the first time. In this work, liquid chromatography coupled to atmospheric pressure chemical ionisation mass spectrometry, high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy were used to identify this new compound. Structure was elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC and (1)H-(1)H COSY. Antioxidant potentialities of a pure compound were evaluated. The estimation of antioxidant capacities using oxygen radical absorbance capacity (ORAC method) and a cell based-assay (WS1) indicated that this new flavonol exhibited the highest antioxidant activities with an ORAC value of 5.0 ± 0.3 μmol Trolox/μmol and inhibited the tBH-induced oxidation of 2',7'-dichlorofluorescin with an IC50 value of 4.9 ± 0.6 μM.


Suaeda fruticosa; flavonol glycoside; high-performance liquid chromatography; mass spectrometry; nuclear magnetic resonance; oxygen radical absorbance capacity

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