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Oncol Lett. 2014 Apr;7(4):1209-1212. Epub 2014 Jan 27.

Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma.

Author information

1
Department of Pediatric Hematology and Oncology, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel ; Cancer Research Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.
2
Cancer Research Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.
3
Department of Neurosurgery, The Chaim Sheba Medical Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.
4
Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA.
5
Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA ; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Tel Aviv 52900, Israel.

Abstract

Related to testes-specific, vespid and pathogenesis protein-1 (RTVP-1), also known as glioma pathogenesis-related protein 1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization class IV). Promoter methylation has been found to control RTVP-1 expression in prostate carcinoma, Wilms' tumor, acute myeloid leukemia and melanoma. In this bi-institutional study, the methylation status of RTVP-1 in astrocytic brain malignancies (GBM and oligodendroglioma) was examined. The RTVP-1 promoter was hypomethylated in GBM compared with non-tumor brain samples, but was hypermethylated in oligodendroglioma. RTVP-1 methylation correlated with RTVP-1 expression at the mRNA level. In GBM, hypermethylation of the RTVP-1 promoter was associated with improved overall survival although with no statistical significance.

KEYWORDS:

glioblastoma; glioma pathogenesis-related protein 1; methylation; related to testes-specific vespid and pathogenesis protein-1

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