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Nat Rev Cancer. 2014 Jul;14(7):495-501. doi: 10.1038/nrc3767. Epub 2014 Jun 19.

Tumour cell invasion: an emerging role for basal epithelial cell extrusion.

Author information

1
Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA.

Abstract

Metastasis is the leading cause of cancer-related deaths, but it is unclear how cancer cells escape their primary sites in epithelia and disseminate to other sites in the body. One emerging possibility is that transformed epithelial cells could invade the underlying tissue by a process called cell extrusion, which epithelia use to remove cells without disrupting their barrier function. Typically, during normal cell turnover, live cells extrude apically from the epithelium into the lumen and later die by anoikis; however, several oncogenic mutations shift cell extrusion basally, towards the tissue that the epithelium encases. Tumour cells with high levels of survival and motility signals could use basal extrusion to escape from the tissue and migrate to other sites within the body.

PMID:
24943812
PMCID:
PMC4393656
DOI:
10.1038/nrc3767
[Indexed for MEDLINE]
Free PMC Article

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