Format

Send to

Choose Destination
Immunol Rev. 2014 Jul;260(1):221-34. doi: 10.1111/imr.12191.

IL-15: a central regulator of celiac disease immunopathology.

Author information

1
Sainte-Justine Hospital Research Center, Department of Microbiology and Immunology, Faculty of Medicine, University of Montreal, Montreal, Canada.

Abstract

Interleukin-15 (IL-15) exerts many biological functions essential for the maintenance and function of multiple cell types. Although its expression is tightly regulated, IL-15 upregulation has been reported in many organ-specific autoimmune disorders. In celiac disease, an intestinal inflammatory disorder driven by gluten exposure, the upregulation of IL-15 expression in the intestinal mucosa has become a hallmark of the disease. Interestingly, because it is overexpressed both in the gut epithelium and in the lamina propria, IL-15 acts on distinct cell types and impacts distinct immune components and pathways to disrupt intestinal immune homeostasis. In this article, we review our current knowledge of the multifaceted roles of IL-15 with regard to the main immunological processes involved in the pathogenesis of celiac disease.

KEYWORDS:

IL-15; autoimmunity; celiac disease; cytotoxic T cells; loss of oral tolerance; tissue

PMID:
24942692
PMCID:
PMC4066219
DOI:
10.1111/imr.12191
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center