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J Pharm Sci. 2014 Aug;103(8):2539-45. doi: 10.1002/jps.24057. Epub 2014 Jun 17.

Titanium dioxide-montmorillonite nanocomposite as photoprotective agent against ultraviolet B radiation-induced mutagenesis in Saccharomyces cerevisiae: a potential candidate for safer sunscreens.

Author information

1
Laboratório de Radiobiologia Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil; Laboratório de Microbiologia e Avaliação Genotóxica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21949-900, Brazil.

Abstract

Photoprotective potential and biological consequences (mutagenic potential) of octyl-dimethyl-PABA (ODP), titanium dioxide (TiO2 ), and montmorillonite (MMT) upon ultraviolet B (UVB) irradiation, alone and in different associations [physical mixtures (PMs)], were evaluated using a Saccharomyces cerevisiae ogg1 mutant (deficient) strain. In addition, we developed and characterized a delaminated TiO2-pillared MMT, called the TiO2 -MMT nanocomposite (NC), which was also investigated in terms of its photoprotective and mutagenic potential. Overall, our results revealed an interesting TiO2 -MMT NC endowed with antimutagenic activity that can be associated to organic sunscreen molecule (ODP) and still maintain its positive effect, whereas its respective PM is unable to grant antimutagenic protection against UVB.

KEYWORDS:

UVB; X-ray diffraction; cerevisiae; clays; layered compounds; montmorillonite; mutagenesis; nanocomposite; nanostructures, nanotechnology; titanium dioxide

PMID:
24942660
DOI:
10.1002/jps.24057
[Indexed for MEDLINE]
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