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PLoS One. 2014 Jun 18;9(6):e98781. doi: 10.1371/journal.pone.0098781. eCollection 2014.

Foldscope: origami-based paper microscope.

Author information

1
Department of Mechanical Engineering, Stanford University, Stanford, California, United States of America.
2
Department of Bioengineering, Stanford University, Stanford, California, United States of America.

Abstract

Here we describe an ultra-low-cost origami-based approach for large-scale manufacturing of microscopes, specifically demonstrating brightfield, darkfield, and fluorescence microscopes. Merging principles of optical design with origami enables high-volume fabrication of microscopes from 2D media. Flexure mechanisms created via folding enable a flat compact design. Structural loops in folded paper provide kinematic constraints as a means for passive self-alignment. This light, rugged instrument can survive harsh field conditions while providing a diversity of imaging capabilities, thus serving wide-ranging applications for cost-effective, portable microscopes in science and education.

PMID:
24940755
PMCID:
PMC4062392
DOI:
10.1371/journal.pone.0098781
[Indexed for MEDLINE]
Free PMC Article

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